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Yes it is safe to give to dogs . I and a few friends i know use it and have discussed this very subjust. We have dertermined that we measure out from the tip of the nail to the first joint on the hand. This comes out to be around an inch. I've used half that for pups as young as 6 wks old and adjust as they mature
This is the same as nemex only a stronger dose than nemex. It will get the roundworms and hookworms only. I use it for my puppies and safeguard horse wormer for the adult dogs.