Nursing female with tapeworm
Moderators: Pike Ridge Beagles, Aaron Bartlett
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Vince Z.
Nursing female with tapeworm
I have a female with 5 day old pups. I noticed a tapeworm in her stool today. I usually use droncit or drontal plus for tapes. Is there a product safe for a nursing bitch or will I have to wait? Thanks for any replies. Vince Z.
DRONCIT®
Active Ingredient
Praziquantel
Category
Endoparasitizides
Target Species
Cat, Dog
Mode of Action
Praziquantel: Praziquantel kills mature and immature development stages of tapeworms in the intestine after a single treatment. Within a few seconds of the tapeworm coming into contact with praziquantel its interaction with phospholipids and proteins causes damage to the tegument. The inflow of Ca+2ions results in an immadiate contraction of the entire strobila. Moreover, these changes lead to a reduction of glucose intake and an accelerated depletion of energy reserves. DRONCIT`s mechanism of action against tapeworms has been investigated with in vitro Hymenolepis diminuta. At very low concentrations (1.0 –10 µg/l) DRONCIT stimulates the motility of H. diminuta and impairs the functional ability of the suckers. At concentrations of 10 – 100 µg/l and above the substance causes very strong contractions of the entire strobila. At concentration of 1 mg/l (1ppm) this contraction takes place the moment the worm comes into contact with the active ingredient solution. This very pronounced in-vitro effect of DRONCIT on tapeworms and the rapid onset of action after the treatment of the host suggest that DRONCIT itself is the cestocidal substance and not its metabolites. The studies of DRONCIT`s mechanism of action against tapeworms performed to date have shown that the drug has an effect on carbohydrate metabolism. The uptake of glucose by the tapeworm is dose-dependently reduced by the administration of DRONCIT: by half at an active concentration of 100 µg/l. The excretion of lactate was not dependent upon the presence of glucose in the surrounding solution. This suggests that lactate excretion is due to an effect on endogenous carbohydrate, probably glycogen. A reduction in the levels of glycogen in worms of the species H. diminuta was detected in rats which has been treated orally with 25 mg DRONCIT/kg: 2 hours after administration the glycogen levels in the worms were 20 – 50% lower than in the worms of the placebo-treated control rats. It was also demonstrated that the tegument of the worms becomes permeable to glucose as a result of the administration of DRONCIT. If H. diminuta treated with DRONCIT were transferred to a glucose-free medium, the parasites released glucose into the surrounding medium.
Indication/Description
Praziquantel: 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin- 4-one (CAS-No. 55268-74-1) ; DRONCIT administered at the recommended dose of 5 mg/kg has been shown to give reliable control of all intestinal growth stages of the following worms: – Echinococcus granulosus – Echinococcus multilocularis – Taenia ovis – Taenia hydatigena – Taenia pisiformis – Taenia taeniaeformis – Taenia multiceps – Dipylidium caninum – Joyeuxiella spp. – Mesocestoides spp.
Chemical Structure
picture - chem_structure_droncit
Method of Administration
The DRONCIT tablet can be administered in the following ways: – directly, – coated in meat or sausage.
Dosage
The standard dose is 5 mg/kg body weight
Drontal Plus:
Removes cestodes (tapeworms), ascarids (roundworms), hookworms, and whipworms from dogs. Broad-spectrum wormer contains three active ingredients: an FDA-approved oral cestode de-wormer plus a de-wormer effective against ascarids and hookworms; and febantel, active against nematodes, including whipworms. These three ingredients utilize different modes of action to rid your dog or puppy of a wide variety of intestinal worms. 50 tablet bottle. Tablets are scored for convenient oral administration. Not for use in pregnant animals. Can be used in puppies at least 4 weeks old with weight exceeding 2 lbs.
Drontal Plus is out! The other doesn't say anything about lactating or puppies. Maybe Doc S can be of more help than the lay person...
Best of luck,
Emery
Active Ingredient
Praziquantel
Category
Endoparasitizides
Target Species
Cat, Dog
Mode of Action
Praziquantel: Praziquantel kills mature and immature development stages of tapeworms in the intestine after a single treatment. Within a few seconds of the tapeworm coming into contact with praziquantel its interaction with phospholipids and proteins causes damage to the tegument. The inflow of Ca+2ions results in an immadiate contraction of the entire strobila. Moreover, these changes lead to a reduction of glucose intake and an accelerated depletion of energy reserves. DRONCIT`s mechanism of action against tapeworms has been investigated with in vitro Hymenolepis diminuta. At very low concentrations (1.0 –10 µg/l) DRONCIT stimulates the motility of H. diminuta and impairs the functional ability of the suckers. At concentrations of 10 – 100 µg/l and above the substance causes very strong contractions of the entire strobila. At concentration of 1 mg/l (1ppm) this contraction takes place the moment the worm comes into contact with the active ingredient solution. This very pronounced in-vitro effect of DRONCIT on tapeworms and the rapid onset of action after the treatment of the host suggest that DRONCIT itself is the cestocidal substance and not its metabolites. The studies of DRONCIT`s mechanism of action against tapeworms performed to date have shown that the drug has an effect on carbohydrate metabolism. The uptake of glucose by the tapeworm is dose-dependently reduced by the administration of DRONCIT: by half at an active concentration of 100 µg/l. The excretion of lactate was not dependent upon the presence of glucose in the surrounding solution. This suggests that lactate excretion is due to an effect on endogenous carbohydrate, probably glycogen. A reduction in the levels of glycogen in worms of the species H. diminuta was detected in rats which has been treated orally with 25 mg DRONCIT/kg: 2 hours after administration the glycogen levels in the worms were 20 – 50% lower than in the worms of the placebo-treated control rats. It was also demonstrated that the tegument of the worms becomes permeable to glucose as a result of the administration of DRONCIT. If H. diminuta treated with DRONCIT were transferred to a glucose-free medium, the parasites released glucose into the surrounding medium.
Indication/Description
Praziquantel: 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin- 4-one (CAS-No. 55268-74-1) ; DRONCIT administered at the recommended dose of 5 mg/kg has been shown to give reliable control of all intestinal growth stages of the following worms: – Echinococcus granulosus – Echinococcus multilocularis – Taenia ovis – Taenia hydatigena – Taenia pisiformis – Taenia taeniaeformis – Taenia multiceps – Dipylidium caninum – Joyeuxiella spp. – Mesocestoides spp.
Chemical Structure
picture - chem_structure_droncit
Method of Administration
The DRONCIT tablet can be administered in the following ways: – directly, – coated in meat or sausage.
Dosage
The standard dose is 5 mg/kg body weight
Drontal Plus:
Removes cestodes (tapeworms), ascarids (roundworms), hookworms, and whipworms from dogs. Broad-spectrum wormer contains three active ingredients: an FDA-approved oral cestode de-wormer plus a de-wormer effective against ascarids and hookworms; and febantel, active against nematodes, including whipworms. These three ingredients utilize different modes of action to rid your dog or puppy of a wide variety of intestinal worms. 50 tablet bottle. Tablets are scored for convenient oral administration. Not for use in pregnant animals. Can be used in puppies at least 4 weeks old with weight exceeding 2 lbs.
Drontal Plus is out! The other doesn't say anything about lactating or puppies. Maybe Doc S can be of more help than the lay person...
Best of luck,
Emery
Be ye kind one unto another, tenderhearted, forgiving one another, even as God for Christ's sake hath forgiven you. Ephesians 4:32
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Guest
I did a google search and found the above information on both medicines. It is greek to me except for what I highlighted Don't give to pregnant females and puppies under 4 weeks old and at least 2 pounds... The other medicine didn't mention anything like that. I would assume that it would be ok to use, but I would really like to know for sure before I administered that kind of thing.
Emery
Emery
Be ye kind one unto another, tenderhearted, forgiving one another, even as God for Christ's sake hath forgiven you. Ephesians 4:32
